Endocrine Abstracts

Small cell lung cancer (SCLC) is highly aggressive with a particularly poor prognosis. This is due to tumours quickly metastasising and developing chemoresistance. SCLC tumours possess neuroendocrine properties in that they secrete prohormones such as pro-opiomelanocortin (POMC) and pro-gastrin releasing peptide (pro-GRP). These can be detected in the circulation and therefore have potential as biomarkers for prognosis and relapse. The aims of this study are; i) develop a mode...

Background: Obese young people are likely to suffer significant morbidity in adult life. Successful intervention during adolescence may have far-reaching benefits. Evidence is emerging that patient-responsive clinical services may deliver improved outcomes.Aims: To assess the perceptions of obese young people about weight and weight-management services.Method: Annonymised, postal questionnaire survey of 116 obese young people (9&#1...

OPUS is a population-based prospective cohort study of post-menopausal women from five European cities. We investigated whether TSH, fT4 and fT3 are associated with fracture risk, bone mineral density (BMD) at hip and spine, bone formation (osteocalcin, procollagen type 1 N-terminal propeptide), bone resorption (N- and C-telopeptides of type 1 collagen, NTX, CTX), pulse rate, grip strength and balance. Vertebral fractures were determined at baseline and 6 years follow-up. Usin...

(This poster is based on OC33)...

Thyroid hormone (T3) is an important regulator of skeletal development and bone turnover. Thyrotoxicosis is associated with accelerated growth, advanced bone age and osteoporosis. T3-action in bone is mediated mainly by T3-receptors (TRs). TRβPV mice harbour a dominant-negative mutation in the TRβ gene that impairs negative feedback control of the hypothalamic-pituitary-thyroid axis resulting in elevated thyroid hormone and TSH concentrations. TRβ<sup...

We report a case of a 76 year old gentleman referred to the endocrine department by his general practitioner (GP) with a few years history of severe lethargy, low mood, and dizziness on changing posture. He is known to have hypothyroidism, hypertension, hypercholesterolaemia, benign prostatic hypertrophy, and benign colonic polyps. His medications included amlodipine, finasteride, lansoprazole, atorvastatin and levothyroxine. Examination of all systems were unremarkable, in pa...

Background: Thyroid hormone (TH) action is mediated by TH receptors (TRs) α&β. Both regulate gene expression by binding TREs on the DNA (canonical signaling) or activate cellular signaling pathways (noncanonical signaling). Bone is a major TH target and noncanonical TR α & β effects on bone metabolism were suggested. We studied mouse model bones to distinguish between signaling types.Methods: Growth of WT mice and mice with ei...

Introduction: Mixed gonadal dysgenesis (MGD) is a rare form of difference in sex development (DSD) characterised by mosaic karyotype of 45,X/46,XY and dysgenetic gonads. Gender dysphoria can be associated, the frequency of which is unknown. We describe 2 cases of MGD with gender dysphoria and the conundrum around pubertal induction.Case 1: An 8-year-old, reared as a girl, presented with longstanding concerns about appear...

Background: Patients with neuroendocrine tumours (NETs) and acromegaly are commonly treated with somatostatin analogs (SSAs), such as octreotide and lanreotide depot formulations. The Pharmathen syringe is now available in several European countries and the USA for lanreotide depot injection. When using SSAs, confidence in and ease of use with syringes are important for decision-making in long-term therapy. The aim of the PRESTO 3 study was to compare nurses’ preference f...

Background: Primary aldosteronism (PA) is the most frequent cause of endocrine hypertension associated with excess aldosterone production from one or both adrenal glands. Somatic or germline mutations in the KCNJ5 potassium channel cause an imbalance in intracellular ion homeostasis. This ultimately drives aldosterone overproduction in some sporadic forms of PA and a familial form of the disease (familial hyperaldosteronism type 3). Our objective was to identify small molecule...